On 25 November a new paper was published by David Tuller (University of California, Berkeley), Caroline Struthers (Oxford University) and myself (Michiel Tack, a long-time ME/CFS patient). The paper is about exercise therapy for chronic fatigue syndrome and bias due to lack of blinding. This blog post provides a short summary.
The paper was published in the journal Fatigue: Biomedicine, Health & Behavior and is called: “Bias caused by reliance on patient-reported outcome measures in non-blinded randomized trials: an in-depth look at exercise therapy for chronic fatigue syndrome.“
Our main analysis focuses on a discrepancy between several randomized trial that report graded exercise therapy (GET) for chronic fatigue syndrome (CFS) is effective and multiple surveys by patient organizations that indicate just the opposite.
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